1962年首先由Bartter报道肾小球球旁细胞增生同时伴有醛固酮分泌增多与低血钾碱中毒2例,称巴特氏综合征。该综合征主要临床特点是低血钾碱中毒血浆肾素活性和血管紧张素增高继发性醛固酮增多;但血压正常或血压偏低,学管壁对血管加压素Ⅱ的加压作用不敏感,肾脏活检可见球旁细胞增生肥大为该综合征的主要特点。 First reported in 1962 by Bartter glomerular mesangial cell proliferation accompanied by increased aldosterone secretion and hypokalemia in 2 cases, called Butter’s syndrome. The main clinical features of the syndrome are hypokalemia poisoning plasma renin activity and angiotensin increased secondary aldosterone increased; but normal blood pressure or blood pressure is low, the tube wall is not sensitive to the pressure of vasopressin Ⅱ Kidney biopsy shows parathyroid hyperplasia hypertrophy of the main features of the syndrome.