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目的探讨复方聚乙二醇电解质散(IV)联合乳果糖口服溶液治疗老年性便秘的临床疗效。方法选取2010年12月—2016年1月内江市第一人民医院收治的老年性便秘患者82例,随机分为对照组和治疗组,每组各41例。对照组口服乳果糖口服溶液,15 m L/次,2次/d。治疗组在对照组治疗基础上口服复方聚乙二醇电解质散(IV),取本品A、B两剂各一包,同溶于125 m L温水中成溶液,开始时1次/d,必要时2次/d,或遵医嘱。两组均连续治疗4周。观察两组的临床疗效,同时比较两组治疗前后症状积分的变化情况。结果治疗后,对照组和治疗组的总有效率分别为87.80%、95.12%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者排便程度评分、粪便性状评分、排便时间评分均显著降低,同组治疗前后差异有统计学意义(P<0.05),且治疗组这些评分的降低程度优于对照组,两组比较差异具有统计学意义(P<0.05)。结论复方聚乙二醇电解质散(IV)联合乳果糖口服溶液治疗老年性便秘具有较好的临床疗效,可明显改善临床症状,安全性较为可靠,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of compound polyethylene glycol electrolyte powder (IV) and lactulose oral solution in the treatment of senile constipation. Methods 82 elderly patients with constipation who were admitted to Neijiang First People’s Hospital from December 2010 to January 2016 were randomly divided into control group and treatment group, 41 cases in each group. The control group oral lactulose oral solution, 15 m L / time, 2 times / d. The treatment group oral administration of polyethylene glycol electrolyte powder (IV) on the basis of the treatment of the control group, take a package of two A and B of the product, dissolved in 125 m L of warm water in solution, 1 time / d, If necessary, 2 times / d, or as directed. Two groups were treated for 4 weeks. The clinical efficacy of the two groups were observed, and the changes of symptom scores before and after treatment were compared between the two groups. Results After treatment, the total effective rate of the control group and the treatment group was 87.80% and 95.12%, respectively, with significant difference between the two groups (P <0.05). After treatment, the defecation score, stool performance score and defecation time score of both groups were significantly decreased, the difference was statistically significant (P <0.05) before and after treatment in the two groups, and the reduction of these scores in the treatment group was better than that in the control group The difference was statistically significant (P <0.05). Conclusion Compound polyethylene glycol electrolyte powder (IV) combined with lactulose oral solution for the treatment of senile constipation has good clinical efficacy, can significantly improve clinical symptoms, the safety is more reliable, and has some clinical application value.