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目的探讨在慢性充血性心力衰竭(心衰)的治疗中联合应用培哚普利与美托洛尔的效果。方法 62例慢性充血性心衰患者,采用双盲法分为观察组(32例)和对照组(30例)。对照组患者单独使用培哚普利治疗,观察组患者在对照组治疗基础上加入美托洛尔。观察两组患者的临床疗效。结果治疗后,观察组患者左室射血分数(LVEF)为(49.5±6.1)%、心率为(66.9±4.4)次/min、舒张压为(65.9±7.0)mm Hg(1 mm Hg=0.133 k Pa)、收缩压为(108.8±9.2)mm Hg,均优于对照组的(38.3±6.8)%、(87.4±3.7)次/min、(80.2±7.3)mm Hg、(127.4±11.5)mm Hg(P<0.05);观察组患者治疗总有效率为93.75%,对照组为70.00%,观察组治疗总有效率明显高于对照组(P<0.05)。结论培哚普利联合美托洛尔治疗慢性充血性心衰的整体效果良好,可在临床中应用并推广。
Objective To explore the combined effect of perindopril and metoprolol in the treatment of chronic congestive heart failure (CHF). Methods Sixty-two patients with chronic congestive heart failure were divided into observation group (32 cases) and control group (30 cases) by double-blind method. Patients in the control group were treated with perindopril alone, while patients in the observation group were given metoprolol on the basis of the control group. To observe the clinical efficacy of two groups of patients. Results After treatment, LVEF was (49.5 ± 6.1)%, heart rate was (66.9 ± 4.4) / min and diastolic pressure was (65.9 ± 7.0) mm Hg (1 mm Hg = 0.133 kPa and systolic blood pressure were 108.8 ± 9.2 mm Hg, which were significantly higher than those in the control group (38.3 ± 6.8%), (87.4 ± 3.7) / min, (80.2 ± 7.3) mm Hg, (127.4 ± 11.5) mm Hg (P <0.05). The total effective rate was 93.75% in the observation group and 70.00% in the control group. The total effective rate in the observation group was significantly higher than that in the control group (P <0.05). Conclusion The overall effect of perindopril combined with metoprolol in the treatment of chronic congestive heart failure is good and can be applied and popularized in clinic.