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肿瘤疫苗的治疗作用是利用肿瘤抗原进行主动免疫来激发、增强机体对肿瘤的主动特异性免疫反应,以阻止肿瘤的生长、扩散和复发。肿瘤免疫的研究已有100多年的历史。人们认识到肿瘤免疫的基础是肿瘤特异性抗原的存在,以及免疫系统对肿瘤细胞的有效应答,并且发现由病毒感染或物理、化学致癌物诱导引起的肿瘤存在肿瘤特异性抗原。Foley早在20世纪50年代,证实对化学致癌物诱导的肿瘤可进行免疫。20世纪60年代,Habel发现多瘤病毒(polyoma virus)表达肿瘤特异性抗原,而且这种抗原与
The therapeutic effect of cancer vaccines is to use tumor antigens for active immunity to stimulate and enhance the body’s active and specific immune response to tumors to prevent tumor growth, proliferation, and recurrence. The study of tumor immunity has a history of more than 100 years. It is recognized that the basis of tumor immunity is the presence of tumor-specific antigens, as well as the immune system’s effective response to tumor cells, and the discovery of tumor-specific antigens in tumors caused by viral infections or induced by physical and chemical carcinogens. Foley, as early as the 1950s, proved immune to tumors induced by chemical carcinogens. In the 1960s, Habel discovered that polyoma virus expresses tumor-specific antigens, and