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目的观察嗜酸乳杆菌片联合三联疗法治疗幽门螺杆菌(Hp)感染的疗效。方法 Hp感染患者258例随机分为三组,分别采用雷贝拉唑+克拉霉素+阿莫西林(三联组,86例)、三联组方案+复方嗜酸乳杆菌(益生菌组,85例)和三联组方案+铋剂(四联组,87例)治疗,测定各组胃黏膜IL-8表达,比较Hp根除率和不良反应发生情况。结果益生菌组Hp根除率为80.0%,高于三联组的60.5%(P<0.05)。益生菌组胃黏膜IL-8含量为(60.7±25.1)pg/ml,低于三联组的(73.1±27.7)pg/ml(P<0.05)。益生菌组腹泻、食欲减退、便秘等不良反应发生率低。结论嗜酸乳杆菌联合三联疗法能显著提高Hp根除率,减轻炎症反应,减少抗生素治疗相关不良反应。
Objective To observe the efficacy of Lactobacillus acidophilus combined with triple therapy in the treatment of Helicobacter pylori (Hp) infection. Methods 258 patients with Hp infection were randomly divided into three groups: rabeprazole + clarithromycin + amoxicillin (triple group, 86 cases), triple combination group + compound Lactobacillus acidophilus (85 cases ) And triple combination group program + bismuth (quadruplex group, 87 cases). The gastric mucosal IL-8 expression in each group was measured. The eradication rate of Hp and the incidence of adverse reactions were compared. Results The eradication rate of Hp in probiotics group was 80.0%, which was higher than 60.5% in triple therapy group (P <0.05). The concentration of IL-8 in the probiotics group was (60.7 ± 25.1) pg / ml, which was lower than that of the triple group (73.1 ± 27.7) pg / ml (P <0.05). Probiotics group, diarrhea, loss of appetite, constipation and other adverse reactions, the incidence of low. Conclusion Lactobacillus acidophilus combined with triple therapy can significantly improve the Hp eradication rate, reduce the inflammatory response and reduce the antibiotic-related adverse reactions.