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β-阻滞疗法对劳累性心绞痛患者有效,其作用方式主要是减少心肌氧耗,但常发生副作用.异搏停也减轻劳累性心绞痛,其作用方式未明,然即使大剂量使用时,副作用也少见.本文在同一组患者中用双盲、安慰剂对照方法比较口服心得安和异搏停的抗心绞痛作用,并测定两药对静息和运动时左室功能的影响.方法:18例有典型劳累性心绞痛史,每周发作≥2次,运动试验阳性的患者(男性17例,女性1例,平均年龄53岁),试验期间除短作用的硝酸酯外停用原来的治疗.先给予二周的安慰剂治疗,然后将安慰剂、心得安和异搏停按3×3Latin设计所确定的顺序进行三个3周的双盲交叉治疗.异搏停
β-block therapy is effective for patients with exestional angina pectoris, the main mode of action is to reduce myocardial oxygen consumption, but often side effects .West pulse stop also relieve angina pectoris, its mode of action is not clear, even if the use of large doses, the side effects are Rare in this same group of patients in a double-blind, placebo-controlled method to compare the efficacy of oral and verapamil anti-angina pectoris and determination of the two drugs on rest and exercise left ventricular function.Methods: 18 cases of The history of typical exertional angina pectoris ≥ 2 episodes per week, exercise test positive patients (17 males and 1 females, mean age 53 years), during the test except for short-acting nitrates, the original treatment was stopped. Two weeks of placebo treatment followed by three 3-week double-blind crossover treatments of placebo, propranolol, and verapamil were performed in the order determined by the 3x3Latin design.