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目的:优选小儿腹泻脐贴的提取工艺条件。方法:以方中的药效成分吴茱萸次碱为评价指标,采用单因素试验和正交试验设计法相结合,优选小儿腹泻脐贴的最佳提取工艺条件。结果:处方中药材的挥发油提取时间为2.5 h;非挥发性有效成分的最佳提取工艺条件为加8倍量70%乙醇,回流提取2次,每次1 h。结论:经工艺验证试验表明,优选出的小儿腹泻脐贴的最佳提取工艺提取率较高,有较好的稳定性、合理、可行。
Objective: To optimize the extraction process conditions of umbilical plaster for pediatric diarrhea. Methods: The efficacy component of carbendazim was used as the evaluation index. The single factor test and orthogonal test design method were combined to optimize the extraction conditions of umbilical plaster for pediatric diarrhea. Results: The extraction time of the volatile oil from prescription Chinese herbal medicines was 2.5 h. The optimum extraction conditions for the non-volatile active ingredients were 8 times 70% ethanol, and the extraction was performed twice under reflux for 1 h each time. Conclusion: The process validation test showed that the optimal extraction process for diarrhea umbilical plaster in children is high, and it has good stability, reasonableness and feasibility.