凝血反应是由一系列凝血因子参与,一种凝血因子以另一种凝血因子为底物的酶促级联放大反应,这种凝血模型被形象地称为瀑布反应模型。Xa因子属于丝氨酸蛋白酶,其在凝血瀑布反应中有着重要作用,可通过内、外源性凝血路径予以激活,其所处位置的特殊性直接决定自身的重要性。本文主要对Xa因子抑制剂的研究新情况进行系统阐述。 The coagulation reaction involves a series of clotting factors, an enzymatic cascade of clotting factors with another clotting factor as the substrate. This clotting model is vividly called the waterfall reaction model. Factor Xa belongs to serine protease, which plays an important role in the coagulation cascade reaction and can be activated by the intrinsic and extrinsic coagulation pathways. The specificity of its location directly determines its importance. This article mainly describes the new situation of Xa factor inhibitor research.