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目的:分析与探讨采用自拟中药组方、阿司匹林以及丙种球蛋白联合治疗川崎病(MCLS)疗效及评价。方法:将临床确诊后进行治疗的122例MCLS病患选择为临床研究病例,根据就诊顺序编号并将单双号分成两组。对照组(单号)61例给予阿司匹林和丙种球蛋白进行治疗,试验组(双号)61例在对照组基础上联合自拟中药组方治疗。比较病患治疗效果、症状消失时间、炎症因子水平及冠状动脉病变情况。结果:试验组患儿冠状动脉病变发生率4.92%、退热时间(2.76±1.02)d、淋巴结肿大消失时间(7.49±1.55)d、皮疹消失时间(4.79±0.78)d、治疗总有效率93.44%、IL-6(17.21±6.01)ng/L、IL-8(180.68±22.08)ng/L、TNF-α(33.99±9.32)ng/L均明显优于对照组冠状动脉病变发生率18.03%、退热时间(3.54±1.33)d、淋巴结肿大消失时间(9.88±2.16)d、皮疹消失时间(6.53±0.47)d、治疗总有效率72.13%、IL-6(30.18±7.14)ng/L、IL-8(240.88±34.85)ng/L、TNF-α(54.18±21.41)ng/L,统计学上有意义(P<0.05)。结论:MCLS病患采用阿司匹林、丙种球蛋白以及自拟中药组方联合治疗,病患各种症状消失时间较快,炎症因子水平明显降低,提高临床治疗效果,有效预防冠状动脉病变,满足患儿及家属期望值。
Objective: To analyze and discuss the curative effect and evaluation of combined treatment of Kawasaki disease (MCLS) with self-made traditional Chinese medicine prescription, aspirin and gamma globulin. Methods: One hundred and twenty-two MCLS patients who were diagnosed after clinical diagnosis were selected as clinical study cases, and were divided into two groups according to the order of treatment and single-double number. Control group (single) 61 patients given aspirin and gamma globulin for treatment, the experimental group (double number) 61 cases in the control group based on the combined treatment of traditional Chinese medicine group. Compare the treatment effect of patients, symptoms disappear time, the level of inflammatory cytokines and coronary lesions. Results: The incidence of coronary artery disease in experimental group was 4.92%, the duration of antipyretic fever (2.76 ± 1.02) d, the disappearance of lymph node enlargement (7.49 ± 1.55) days and the disappearance of rash (4.79 ± 0.78) d, the total effective rate 93.44%, IL-6 (17.21 ± 6.01) ng / L, IL-8 (180.68 ± 22.08) ng / L and TNF-α (33.99 ± 9.32) ng / L were significantly higher than the control group, the incidence of coronary artery lesions was 18.03 (3.54 ± 1.33) d, duration of disappearance of lymph nodes (9.88 ± 2.16) d and disappearance of rash (6.53 ± 0.47) d, respectively. The total effective rate was 72.13% IL-8 (240.88 ± 34.85) ng / L, TNF-α (54.18 ± 21.41) ng / L, statistically significant (P <0.05). Conclusion: The treatment of MCLS patients with aspirin, gamma globulin and self-made Chinese medicine combined treatment of various symptoms of patients disappear faster, significantly reduce the level of inflammatory cytokines, improve clinical treatment, effective prevention of coronary artery disease, to meet the children And family expectations.