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De Bold等在1981年实验后即证明心房组织的利钠活性与心房的特异性颗粒有关,并证实含有强大利钠作用和松弛血管的肽,这种肽被命名为利钠因子。 过去5年间,作了大量的工作,完成了分离、弄清了氨基酸的排列顺序并合成了这种有活性的多肽。另外,更多地认识了心房利钠肽(ANP)的生理、药理及其在某些心血管疾病中的作用机理。本文目的是强调
De Bold et al. Demonstrated in 1981 that the sodium activity of atrial tissue is associated with atrial-specific particles and confirmed the presence of a potent natriuretic and relaxing vascular peptide, which is named Natriuretic factor. In the past 5 years, a great deal of work has been done to complete the separation, clarify the order of amino acids and synthesize this active polypeptide. In addition, more understanding of the atrial natriuretic peptide (ANP) physiology, pharmacology and its mechanism of action in certain cardiovascular diseases. The purpose of this article is to emphasize