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目的 探讨急性白血病血清促红细胞生成素 (sEP0 )与血红蛋白 (Hb)的关系。方法 采用放射免疫分析法测定sEP0 ,采用常规血细胞计数仪测定Hb。结果 sEP0与Hb之间在ALL治疗前、4周缓解组均呈负相关关系 (分别为 r =-0 4 2 7,-0 5 5 7,P均 <0 0 5 ) ;AML治疗前呈负相关关系 (r =-0 6 5 1,P<0 0 5 ) ,缓解后无相关性 (r =-0 6 30 ,P >0 0 5 )。结论 急性白血病患者sEP0与Hb在急性白血病治疗前呈负相关关系 ,缓解后无相关性。因此 ,白血病贫血不是由于EP0的生成不足导致的 ,用rHuEP0治疗效果可能有限。
Objective To investigate the relationship between serum erythropoietin (sEP0) and hemoglobin (Hb) in acute leukemia. Methods Radioimmunoassay was used to determine sEP0 and Hb was measured by routine hematology analyzer. Results There was a negative correlation between sEP0 and Hb before and 4 weeks after remission (r = -0.427, -0.557 respectively, all P <0 05). AML was negative before treatment (R = -0 6 5 1, P 0 05). There was no correlation after remission (r = -0 6 30, P 0 05). Conclusions There is a negative correlation between sEP0 and Hb in patients with acute leukemia before treatment of acute leukemia and no correlation after remission. Thus, anemia of leukemia is not due to underproduction of EPO, and treatment with rHuEPO may be limited.