乙胺丁醇服用后绝大部分以游离形式从尿中排出。因此,可以采用尿药法来测定乙胺丁醇的生物利用度及动力学参数。据文献报道,国外测定乙胺丁醇的法定方法是非水滴定。一些非法定方法有微生物法、铜离子络合比色法、酸性染料法、传荷络合物法等。体内微量乙胺丁醇的测定,国内没有报道,国外近十多年来,多采用GLC 法。本实验着重考察了酸性染料法对体内微量乙胺丁醇的测定,并用尿药法在5个 Ethambutol after taking the vast majority of free form from the urine. Therefore, the urinary method can be used to determine the bioavailability and kinetic parameters of ethambutol. According to the literature, the legal method for the determination of ethambutol abroad is non-aqueous titration. Some non-statutory methods include microbial method, copper ion complexation colorimetric method, acid dye method, charge-transfer complex method and so on. Determination of trace amounts of ethambutol in vivo, there is no report in the country, nearly a decade abroad, the use of GLC method. This experiment focused on the acid dye method for the determination of trace amounts of ethambutol in vivo and urine method in 5