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目的研究牙周炎症对冠状动脉性心脏病(冠心病)患者氧化低密度脂蛋白(ox-LDL)和纤维蛋白原(Fg)的影响。方法连续入选冠心病患者168例和非冠心病患者146例,通过问卷调查、牙周检查以及血液ox-LDL和Fg水平测定进行冠心病危险因素分析。结果冠心病组牙周炎发生率显著高于非冠心病组(75.6%比59.6%,P<0.05);冠心病合并慢性牙周炎患者ox-LDL和Fg水平显著高于单纯冠心病组[ox-LDL(543.8±187.8)比(448.8±76.0)μg/L;Fg(4.01±0.75)比(3.69±0.68)g/L,均P<0.05]。趋势检验结果显示,随着牙周炎程度的加重,患冠心病的风险也愈大(P<0.01);logistic回归分析显示,慢性牙周炎是冠心病的危险因素之一(P<0.05)。结论冠心病合并慢性牙周炎伴有更高水平的ox-LDL和Fg,慢性牙周炎可能是冠心病的危险因素之一。
Objective To investigate the effects of periodontal inflammation on oxidized low density lipoprotein (ox-LDL) and fibrinogen (Fg) in patients with coronary heart disease (CHD). Methods A total of 168 patients with coronary heart disease and 146 patients without coronary heart disease were enrolled in this study. Risk factors of coronary heart disease were analyzed by questionnaire, periodontal examination and blood ox-LDL and Fg levels. Results The incidence of periodontitis in CHD group was significantly higher than that in CHD group (75.6% vs 59.6%, P <0.05). The levels of ox-LDL and Fg in CHD patients with chronic periodontitis were significantly higher than those in CHD group [ ox-LDL (543.8 ± 187.8) vs (448.8 ± 76.0) μg / L; Fg (4.01 ± 0.75) vs (3.69 ± 0.68) g / L, all P <0.05]. The results of trend test showed that the risk of coronary heart disease increased with the severity of periodontitis (P <0.01). Logistic regression analysis showed that chronic periodontitis was one of the risk factors of coronary heart disease (P <0.05) . Conclusions Coronary heart disease complicated with chronic periodontitis is associated with higher levels of ox-LDL and Fg. Chronic periodontitis may be one of the risk factors of coronary heart disease.