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1968～1970年 Fulham 医院的肾透析单位病人中发生 HBsAg 阴性肝炎爆发。共有29例急性肝炎,8例(28%)发展为慢性肝病,其中7例进行肝活检,证明为慢性活动性肝炎3例,慢性迁延性肝炎2例,非特异性肝炎伴铁过度负荷2例。鉴于目前已建立甲型肝炎的血清学诊断技术,乃将原来采集的血清应用免疫粘连血凝法测定甲型肝炎抗体(抗-HAV),以明确病因。共取得24例血清,每例选择2份,其中12份为发病前和发病数月以后的双份血清。21例抗-HAV 滴度无变化,仅1例轻度升高(由<10→100),2例滴度下降(由≥1,000→<10),这2例后来均转变为
An outbreak of HBsAg-negative hepatitis occurred in renal dialysis units at Fulham Hospital from 1968 to 1970. A total of 29 cases of acute hepatitis, 8 cases (28%) developed chronic liver disease, of which 7 cases of liver biopsy proved to be chronic active hepatitis in 3 cases, 2 cases of chronic persistent hepatitis, non-specific hepatitis with iron overload in 2 cases. In view of the current established serological diagnosis of hepatitis A, the hepatitis A antibody (anti-HAV) was determined by the immunohistochemistry of the originally collected serum to clarify the cause. A total of 24 cases of serum obtained, each selected 2 copies, of which 12 before onset and onset of several months after the double serum. There was no change in the titer of anti-HAV in 21 patients, with only 1 mild increase (from <10 → 100) and 2 titers (from ≥1,000 to <10), both of which later changed to