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一、有关乙型肝类各种抗原、抗体的出现、消失及其与临床的关系:以肝活检的薄切片作电镜检查,显示HBsAg是在胞浆内,HBcAg是在胞核内。乙型肝炎病毒在肝细胞内复制,并将复制的感染粒子释放入血循环。而HBsAg似乎非常超量地合成,以致过量的抗原作为不完整、非感染的20nm球形或管形颗粒由肝细胞释放入血液,并以游离的形式循环。血液中HBsAg数量颇大,可有10~(13-14)颗粒/毫升那么多。 HBsAg最初检出是在本病潜伏期,即症状发作前4～6周。而后抗原滴度逐步上
First, the various Hepatitis B antigens, antibodies appear, disappear and its relationship with the clinical: Liver biopsy thin sections for electron microscopy showed that HBsAg is in the cytoplasm, HBcAg is in the nucleus. Hepatitis B virus replicates in hepatocytes and releases the replicated infectious particles into the bloodstream. While HBsAg appears to be synthesized excessively so that an excess of antigen is released as incomplete, uninfected 20 nm spherical or tubular particles from the liver cells into the blood and circulates in free form. The amount of HBsAg in the blood is quite large, there may be 10 ~ (13-14) particles / ml so much. The initial detection of HBsAg is the incubation period of the disease, that is, 4 to 6 weeks before the onset of symptoms. Then the antigen titers gradually