生活在疟疾地方性流行区的人对疟疾抗原的细胞免疫及体液免疫的反应会按季节发生波动,疟疾呈季节性传播地区尤其明显。最显著的变化是与临床发作相伴随,但是无症状的疟疾感染亦能产生明显的免疫抑制。最近的资料显示对疟疾的细胞免疫反应的季节性变化,甚至可以在未查到原虫时发生。本文将阐述人类对疟疾免疫反应的季节性变化,并探讨其可能原因。 People living in endemic areas of malaria respond to the cellular and humoral immunity to malaria antigens on a season-by-season basis, especially in areas where seasonal malaria is endemic. The most significant change is associated with clinical seizures, but asymptomatic malaria infections can also produce significant immunosuppression. Recent data show that seasonal changes in the cellular immune response to malaria can even occur when protozoa is not detected. This article describes the seasonal changes in human immune response to malaria and explores its possible causes.