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本研究采用盲肠结扎加戳孔（CLP）复制大鼠腹腔感染模型，分别在8hr、16hr对大鼠耳廓及本模型中损伤较重的肠系膜、肠壁微循环进行了动态观察比较。结果显示，CLP组上述各部位微循环均呈相同程度的炎性变化，且随时间延长而加重。用654－2治疗后血液流态有所改善；假手术对照组，仅肠系膜微循环有轻度的炎性变化，耳廓微循环无明显改变。本研究充分说明局部严重感染尤其导致全身反应时，通过外周微循环监测可以及时反映内脏微循环的变化。但局部轻度感染时，外周皮肤微循环变化并不一致。因此，在临床工作中常用的甲襞等部位外周微循环的监测在病变程度上存在一定的选择性。
In this study, cecal ligation plus puncturing (CLP) was used to replicate the rat model of intraperitoneal infection, and the microcirculation of the mesentery and the intestinal wall in the auricles of the rats and in the model were observed at 8 and 16 hours respectively. The results showed that the microcirculation in all the above groups of CLP showed the same degree of inflammatory changes, and aggravated with time. After treatment with 654-2 blood flow improved; sham operation control group, only mesenteric microcirculation mild inflammatory changes, auricle microcirculation no significant change. This study fully shows that when local serious infection especially leads to systemic reaction, the change of visceral microcirculation can be timely reflected by peripheral microcirculation monitoring. However, mild local infection, peripheral skin microcirculation changes are not consistent. Therefore, in the clinical work commonly used in formazan and other parts of the peripheral microcirculation monitoring in the extent of the disease there is a certain degree of selectivity.