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目的:探讨体外膈肌起搏长期治疗对慢性阻塞性肺病(COPD)患者的呼吸肌功能疗效。方法:30例COPD缓解期患者,在住院期间接受2周体外膈肌起搏治疗(EDP),然后分为家庭继续治疗组(继治组)和停止治疗组(停治组)各15例,每组患者在治疗前、治疗2周,治疗或停止治疗6周及16周分别测定口腔最大吸气压(MIP),负荷呼吸时间(LT)、膈肌移动度(DM)和6分钟行走距离(6MWD)。结果:EDP 2周治疗后两组MIP、LT和6MWD、DW均有明显增加,与治疗前相比示显著差异(P<0.05),继治组治疗后随时间推延期MIP、LT、6MWD和DM有进一步提高(P<0.05),停治组其疗效示逐渐减退,16周后已降至治疗前水平(P<0.05)。结论:长期EDP治疗是提高COPD患者呼吸肌功能的有效方法。
Objective: To investigate the efficacy of long-term diaphragmatic pacing in vitro on respiratory muscle function in patients with chronic obstructive pulmonary disease (COPD). Methods: Thirty patients with COPD during remission received 2 weeks of in vitro diaphragmatic pacing (EDP) during hospitalization and then divided into 15 consecutive cases of family continuation therapy (follow-up group) and stop treatment group (control group) The patients were tested for MIP, LT, DM and 6MWD before treatment, 2 weeks, 6 weeks and 16 weeks after treatment or discontinuation of treatment, respectively. ). Results: The levels of MIP, LT, 6MWD and DW in the two groups after EDP 2 weeks treatment were significantly increased (P <0.05), compared with those before treatment (P <0.05) DM was further improved (P <0.05), the treatment group showed a gradual decline in its efficacy, after 16 weeks has dropped to pre-treatment levels (P <0.05). Conclusion: Long-term EDP treatment is an effective method to improve respiratory muscle function in COPD patients.