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测定三种溶血性疾病患者的红细胞膜蛋白质与脂质(胆固醇/磷脂摩尔比值;C/PL)。方差分析表明,阵发性夜间血红蛋白尿(PNH)、慢性再生障碍性贫血(AA)和遗传性球形红细胞症(HS)患者红细胞膜骨架蛋白的各主要多肽组分含量同正常对照组相比,无显著差异;其 C/PL 亦在正常范围。而组间 t 检验则提示,AA 和 PNH 患者红细胞膜的区带6百分含量却极显著地高于正常组(P<0.01)。但这些改变却不是该两种溶血性疾病患者红细胞膜缺陷的本质原因。
Erythrocyte membrane protein and lipid (cholesterol / phospholipid molar ratio; C / PL) were measured in three patients with hemolytic disease. Analysis of variance showed that the contents of major polypeptide components of erythrocyte membrane scaffold protein in patients with paroxysmal nocturnal hemoglobinuria (PNH), chronic aplastic anemia (AA) and hereditary spherocytosis (HS) were significantly higher than those in the normal control group No significant difference; its C / PL is also in the normal range. The t-test showed that the 6% of the erythrocyte membrane area in patients with AA and PNH was significantly higher than the normal group (P <0.01). However, these changes are not the essential cause of erythrocyte membrane defects in patients with both hemolytic diseases.