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目的观察调中颗粒联合复方阿嗪米特肠溶片治疗功能性消化不良(FD)所致腹胀的疗效。方法 210例FD患者随机分为治疗组(调中颗粒联合复方阿嗪米特肠溶片)和对照组(单用复方阿嗪米特肠溶片),分别每天3次给予调中颗粒/复方阿嗪米特肠溶片治疗共4周。观察两组治疗前后腹胀症状积分变化、腹胀改善总有效率及药物副作用。患者治疗前后进行水负荷试验。结果与对照组相比,治疗组治疗4周末时腹胀症状积分明显下降(P<0.05),治疗组腹胀改善总有效率为92.1%,与对照组70.1%比较,有显著性差异(P<0.05)。治疗过程中各组均未出现严重的药物副作用。结论调中颗粒联合复方阿嗪米特肠溶片能缓解FD患者腹胀症状,两者之间具有一定协同作用,并具有较好的安全性。
Objective To observe the effect of Tazhong granules combined with compound azinamid enteric-coated tablets in the treatment of abdominal distension caused by functional dyspepsia (FD). Methods A total of 210 patients with FD were randomly divided into treatment group (Tazhong Granule combined with compound Azimilate enteric-coated tablets) and control group (Compound Azimilate enteric-coated tablets alone) Alliazide enteric-coated tablets for 4 weeks. Observed before and after treatment in both groups changes in symptoms of bloating, abdominal distension to improve the total effective rate and drug side effects. Patients before and after treatment of water load test. Results Compared with the control group, the scores of abdominal distension symptoms in the treatment group decreased significantly at the end of 4 weeks (P <0.05), and the total effective rate of the treatment group was 92.1%, which was significantly lower than that of the control group (70.1%, P <0.05) ). During the course of treatment, no serious side effects were observed in all the groups. Conclusion Tiazhong granules combined with compound azinamid enteric-coated tablets can alleviate the symptoms of abdominal distension in patients with FD, with some synergy between the two and has good safety.