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应用双抗体夹心法检测了３０例ＨＢＶ、ＨＣＶ重叠感染患者血清ＴＮＦα及ＩＬ－６水平明显高于ＨＢＶ或ＨＣＶ单纯感染者，并与血清ＴＢｉｌ水平呈正相关，死亡者该两种细胞因子水平明显高于存活者。提示：ＴＮＦα和ＩＬ－６的升高可能是导致ＨＢＶ、ＨＣＶ重叠感染者病情重、预后差的重要因素之一，并可以作为衡量其病情变化及预后的有效指标。
Serum levels of TNFα and IL-6 in 30 patients with HBV and HCV co-infection were significantly higher than those with HBV or HCV infection by double-antibody sandwich assay, and were positively correlated with serum TBil levels. The levels of these two cytokines in patients with death were significantly higher For survivors. It is suggested that the increase of TNFα and IL-6 may be one of the important factors that lead to severe illness and poor prognosis of HBV and HCV overlap infection, and can be used as an effective index to measure the change of disease and prognosis.