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目的：研究胎儿过熟综合征（病理性过期妊娠）时母血、脐血及羊水中 Ｆ Ｅ３ 及 Ｈ Ｐ Ｌ 变化的临床意义。方法：采用放射免疫检测方法对 ４０ 例妊娠 ４０ 周后伴胎儿过熟综合征病例及 ４２ 例生理性过期妊娠肘静脉血、脐静脉血及羊水中 Ｆ Ｅ３ 及 Ｈ Ｐ Ｌ 进行检测，同时与５０ 例足月妊娠进行对照。结果：病理性过期妊娠组母血、脐血及羊水中 Ｆ Ｅ３ 浓度显著低于其它组，各样本 Ｈ Ｐ Ｌ 浓度从足月妊娠至病理性过期妊娠急剧下降，各组间有统计学意义。结论： Ｆ Ｅ３ 和 Ｈ Ｐ Ｌ 能准确反映足月妊娠后胎盘功能下降程度，提示病理性过期妊娠时低体重儿发生率高与胎盘 Ｈ Ｐ Ｌ 合成减少有关。
Objective: To study the clinical significance of the changes of F E3 and H P L in maternal blood, umbilical cord blood and amniotic fluid during fetal overmature syndrome (pathological obesity pregnancy). Methods: Radioimmunoassay was used to detect F E3 and H P L in 40 cases of pregnancy complicated with fetal over-syndrome and 42 cases of physiologically overdue pregnancy in the elbow venous blood, umbilical cord blood and amniotic fluid at the same time. Cases of full-term pregnancy control. Results: F E3 concentrations in maternal blood, umbilical cord blood and amniotic fluid were significantly lower than those in other groups in the pathological obesity group. The concentrations of H P L in all the samples from the full-term pregnancy to the pathological over-pregnancy were significantly decreased. There was statistical significance among the three groups. CONCLUSION: F E3 and H P L can accurately reflect the decline of placental function after term pregnancy, suggesting that the high incidence of low birth weight infants with pathologic abnormal pregnancy is related to the decrease of placental H P L synthesis.