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临床上哮喘的管理依赖于对症状和肺功能的监测。然而,即使是肺功能正常和临床上已被完全控制的哮喘患者,还呈现有气道炎症,表明这些检测方法反映气道炎症还不够敏感。诱导排出痰中的嗜酸粒细胞和呼出气NO为现今评定气道炎症的非侵入性标记物。未接受吸入性类固醇治疗患者的痰嗜酸粒细胞(％)和呼出气NO两者均增高,并随着皮质类固醇治疗而降低,这两者之间似乎存在着一种相关性。支气管高反应性(BHR)为哮喘的关键性特征,且可作为哮
The management of asthma clinically depends on the monitoring of symptoms and lung function. However, even asthmatic patients with normal lung function and complete clinical control have airway inflammation, indicating that these tests are not sensitive enough to reflect airway inflammation. Induction of eosinophils and exhaled breath in sputum NO is a noninvasive marker for assessing airway inflammation today. There seems to be a correlation between the sputum eosinophils (%) and exhaled NO in patients not receiving inhaled steroids, both of which are elevated with corticosteroid treatment. Bronchial hyperresponsiveness (BHR) is a key feature of asthma, and can be used as asthma