【非细胞毒药物】肺受损害的机制非细胞毒药物所致肺损伤的机制不如已知的细胞毒药物明确,但和细胞毒药物相似,肺内自稳功能紊乱可能在肺损伤中起重要作用(见表4)。氧化与抗氧化系统呋喃(口旦)啶通过产生活性氧基,引起肺损伤,已有3份报告经体外试验证实,该药存在时,肺微粒体产生氧基,如 [Non-cytotoxic drugs] Mechanisms of lung damage Non-cytotoxic drug-induced lung injury is less well known than known cytotoxic drugs, but similar to cytotoxic drugs, pulmonary homeostasis may play a role in lung injury Role (see table 4). Oxidation and Antioxidant Systems Furan (denudan), which causes lung damage by generating reactive oxygen species, has been reported in three in vitro tests that show the presence of oxygen in the lung microsome when present