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目的 :研究人嗜T淋巴细胞病毒Ⅰ型相关性脊髓病 /热带痉挛性瘫痪 (HAM/TSP)外周血淋巴细胞凋亡情况 ,以及患者血浆及脑脊液 (CSF)中sFas、sFasL的表达水平在HAM/TSP发生、发展中的作用。方法 :用单细胞电泳检测HAM /TSP患者外周血淋巴细胞的凋亡情况 ,ELISA方法检测HAM/TSP患者血浆及CSF中存在的sFas、sFasL。结果 :HAM/TSP患者外周血淋巴细胞凋亡率明显增高 ,与正常对照组比较有统计学意义 (P <0 0 5 ) ;患者血浆sFas、sFasL表达水平与其他神经系统感染性疾病 (OIND)及正常对照组相比显著增高 (P <0 0 5 ) ;血浆sFasL表达水平高于OIND及正常对照组 (P >0 0 5 ) ;CSF、sFas、sFasL表达水平均高于OIND组 (P <0 0 5 )。结论 :淋巴细胞凋亡及凋亡相关因子sFas、sFasL可能在HAM/TSP的发生、发展中起重要作用
Objective: To study the apoptosis of peripheral lymphocytes in human type I-associated myelopathy / tropical spastic paraplegia (HAM / TSP) and the expression of sFas and sFasL in plasma and cerebrospinal fluid (CSF) / TSP occurred, the role of development. Methods: The apoptosis of peripheral blood lymphocytes in HAM / TSP patients was detected by single cell electrophoresis. The sFas and sFasL were detected by ELISA in plasma and CSF of HAM / TSP patients. Results: The apoptosis rates of peripheral blood lymphocytes in HAM / TSP patients were significantly higher than those in normal controls (P <0.05). The levels of sFas and sFasL in plasma and other neurological infectious diseases (OIND) SFas and sFasL were significantly higher than those in OIND group (P <0.05). The levels of sFasL in plasma were higher than those in OIND and normal controls (P> 0.05) 0 0 5). Conclusion: The apoptosis of lymphocytes and apoptosis related factors sFas, sFasL may play an important role in the occurrence and development of HAM / TSP