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研究了８名健康志愿者口服单剂国产司帕沙星４００ｍｇ后的药物动力学特征。用高效液相色谱法（ＨＰＬＣ）测定血清和尿中药物浓度。该药在体内转运过程以二室模型拟合为佳。峰浓度（Ｃｍａｘ为１４９±０．２８ｍｇ／Ｌ，达峰时间（Ｔｍａｘ）为７．１２±１．１７ｈ，消除半衰期（Ｔ１／２β）为２２±６．８３ｈ，系统清除率（Ｃｌｍ）为８．８５±２．１６Ｌ／ｈ，表观分布容积（Ｖｄ）为２．７３Ｌ／ｋｇ，血药－时曲线下面积（ＡＵＣ）为４７．３５±１０．２４（ｍｇｈ）／Ｌ，滞后时间（Ｔｌａｇ）为０．８９±０．８８ｈ。服药后２４、９６ｈ尿药排泄率仅为９．１６％和１５．６８％。
Pharmacokinetic characteristics of a single dose of sparfloxacin 400 mg were studied in eight healthy volunteers. Serum and urine drug concentrations were determined by high performance liquid chromatography (HPLC). The drug is best fitted in a two-compartment model during in vivo transit. The peak concentration (Cmax 149 ± 0.28mg / L, peak time (Tmax) 7.12 ± 1.17h, elimination half-life (T1 / 2β) 22 ± 6.83h, the system clearance rate .85 ± 2.16 L / h, the apparent volume of distribution (Vd) was 2.73 L / kg, the AUC was 47.35 ± 10.24 (mgh) / L, Tlag) was 0.89 ± 0.88h, urinary excretion rate was only 9.16% and 15.68% at 24 and 96 hours after taking the drug.