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研究了8名健康志愿者口服单剂国产司帕沙星400mg后的药物动力学特征。用高效液相色谱法(HPLC)测定血清和尿中药物浓度。该药在体内转运过程以二室模型拟合为佳。峰浓度(Cmax为149±0.28mg/L,达峰时间(Tmax)为7.12±1.17h,消除半衰期(T1/2β)为22±6.83h,系统清除率(Clm)为8.85±2.16L/h,表观分布容积(Vd)为2.73L/kg,血药-时曲线下面积(AUC)为47.35±10.24(mgh)/L,滞后时间(Tlag)为0.89±0.88h。服药后24、96h尿药排泄率仅为9.16%和15.68%。
Pharmacokinetic characteristics of a single dose of sparfloxacin 400 mg were studied in eight healthy volunteers. Serum and urine drug concentrations were determined by high performance liquid chromatography (HPLC). The drug is best fitted in a two-compartment model during in vivo transit. The peak concentration (Cmax 149 ± 0.28mg / L, peak time (Tmax) 7.12 ± 1.17h, elimination half-life (T1 / 2β) 22 ± 6.83h, the system clearance rate .85 ± 2.16 L / h, the apparent volume of distribution (Vd) was 2.73 L / kg, the AUC was 47.35 ± 10.24 (mgh) / L, Tlag) was 0.89 ± 0.88h, urinary excretion rate was only 9.16% and 15.68% at 24 and 96 hours after taking the drug.