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目的:观察“四大血”不同剂量提取物对急性血瘀大鼠血液流变学的影响。方法:采用大剂量注射肾上腺素加寒冷剌激的方法制备大鼠急性血瘀模型,给予不同剂量的“四大血”提取物,测定实验动物的血液流变学指标。结果:“四大血”的水提醇沉液的高(4g/kg)、中(2g/kg)、低(1g/kg)剂量组在切变率为1/s、5/s、50/s时可显著降低全血黏度;其高、低剂量组可显著降低全血还原黏度、红细胞聚集指数,而对红细胞压积和血浆黏度无明显影响。结论:“四大血”能够改善急性血瘀模型大鼠血液流变学的相关指标,具有一定活血化瘀作用。
Objective: To observe the effects of different doses of “Si Dao Xue” on hemorrheology in acute blood stasis rats. Methods: Acute blood stasis model was prepared by injection of epinephrine and cold stimulation at high dose, and different doses of “four major blood” extracts were given to determine the hemorrheological indexes of experimental animals. Results: The results showed that when the shear rate was 1 / s, 5 / s (2g / kg) and low (1g / , 50 / s can significantly reduce the whole blood viscosity; high and low dose group can significantly reduce the reduction of whole blood viscosity, erythrocyte aggregation index, but no significant effect on hematocrit and plasma viscosity. Conclusion: “Four major blood” can improve the relevant indexes of hemorrheology in acute blood stasis model rats, and has some functions of promoting blood circulation and removing blood stasis.