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阿霉素的主要副作用表现为对心肌的损伤效应。门冬氨酸钾镁通过门冬氨酸的载体作用.使细胞内钾镁离子浓度明显增加。国外学者曾报道镁可使心肌组织免受药物的损伤。为此.我们分别采用体外心肌细胞培养和在体动物模型.观察门冬氨酸钾镁对阿霉素性心肌损伤的影响。以2～3 d龄Wistar大鼠的心肌细胞为实验材料.取培养3 d的心肌细胞19瓶.随机分成阿霉素组(n=10)和门冬氨酸钾镁加阿霉素组(n=9)(门冬氨酸钾镁系上海海普药厂产品.含钾10g·L~(-1).镁4g·
The main side effects of doxorubicin appear to be myocardial damage effects. Potassium and magnesium aspartate act as a carrier of aspartic acid, causing a significant increase in the concentration of potassium and magnesium ions in the cells. Foreign scholars have reported that magnesium can make myocardial tissue from drug damage. To this end, we used in vitro cardiomyocyte cultures and in vivo animal models to observe the effects of potassium and magnesium aspartate on adriamycin-induced myocardial injury. The myocardial cells from 2 to 3 days old Wistar rats were taken as experimental materials, 19 bottles of cultured cardiomyocytes were cultured for 3 days, then randomly divided into doxorubicin group (n = 10) and potassium magnesium aspartate plus doxorubicin group n = 9) (Potassium magnesium aspartate Shanghai Haipu pharmaceutical products. Potassium 10g · L ~ (-1). Magnesium 4g ·