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将多柔比星（ＡＤＭ）纳米微粒（小粒径脂质体与毫微粒）与碘油制成乳剂经肝动脉栓塞治疗大鼠Ｗ２５６ 肝癌模型。结果表明，与同剂量游离ＡＤＭ 及生理盐水对照组相比，ＡＤＭ 纳米微粒－碘油乳剂治疗组对肿瘤生长抑制明显提高（Ｐ＜ ０．０１），肿瘤坏死彻底，而大鼠的生存延长期则显著延长（Ｐ＜ ０．０１）。高效液相色谱测定结果表明纳米微粒－碘油乳剂治疗组ＡＤＭ 在体内的分布以肝、脾组织为主，说明用ＡＤＭ 纳米微粒－碘油乳剂肝动脉栓塞治疗肝癌能降低毒性，提高治疗效果。
Rat W256 hepatocellular carcinoma model was treated with transcatheter arterial embolization of doxorubicin (ADM) nanoparticles (small size liposomes and nanoparticles) and lipiodol. The results showed that, compared with the same dose of free ADM and saline control group, ADM nanoparticles - lipiodol emulsion treatment group significantly increased tumor growth inhibition (P <0.01), complete tumor necrosis, and prolonged survival of rats Was significantly longer (P <0.01). The results of HPLC showed that the distribution of ADM in the nanoparticle-lipiodol emulsion treatment group mainly consisted of liver and spleen, indicating that the treatment of liver cancer with ADM nanoparticle-lipiodol emulsion hepatic arterial embolization can reduce the toxicity and improve the therapeutic effect.