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目的：探讨复方丹参注射液对急性汞中毒的治疗作用。方法：采用皮下注射１０ｇ／Ｌ氯化高汞（１．７ｍｌ／ｋｇ）引起家兔急性汞中毒的动物模型（汞中毒组），测定血浆及组织匀浆中丙二醛（ＭＤＡ）含量及肺组织中卵磷脂（ＰＣ）和总磷脂（ＴＰＬ）含量，同时检测血尿素氮（ＢＵＮ）浓度及尿常规；并与中毒后复方丹参注射液组（治疗组）和生理盐水对照组比较。结果：汞中毒后２４小时血浆和组织中ＭＤＡ含量均明显增加（Ｐ＜０．０５或Ｐ＜０．０１）；血ＢＵＮ浓度升高，与汞中毒前及对照组比较均有显著性差异（Ｐ均＜０．０１）；尿蛋白及尿镜检均为（＋＋＋＋）；肺组织ＰＣ及ＴＰＬ含量与对照组比较均明显减少（Ｐ均＜０．０１）。注射氯化高汞后给予复方丹参注射液可减少ＬＰＯ生成，降低ＢＵＮ水平，逆转尿的改变，且能防止肺表面活性物质（ＰＳ）减少。结论：急性汞中毒后不仅损害肾脏，而且累及肺脏，其ＰＳ减少可能与ＭＤＡ增加有关；复方丹参注射液能抑制这一过程，进而减轻汞的致毒效力
Objective: To investigate the therapeutic effect of Fufang Danshen injection on acute mercury poisoning. Methods: Animal models of acute mercury poisoning (mercury poisoning group) caused by 10g / L high mercury (1. 7ml / kg) chloride were injected subcutaneously. The content of malondialdehyde (MDA) in plasma and tissue homogenate The levels of lecithin (PC) and total phospholipid (TPL) in the tissues were measured. The blood urea nitrogen (BUN) and urinary routine were measured simultaneously. The levels of BUN and urine were compared with those of the Salvia miltiorrhiza injection group and the saline control group. Results: The contents of MDA in plasma and tissue increased significantly 24 hours after mercury poisoning (P <0.05 or P <0.01), and the levels of blood BUN were significantly higher than those before mercury poisoning (P <0.05 or P <0.01) P <0.01). Urinary protein and urinalysis were all (++++). The contents of PC and TPL in lung tissue were significantly decreased compared with the control group (all P <0.01). Compound Salviae Miltiorrhizae injection can reduce the production of LPO, decrease the level of BUN, reverse the change of urine, and prevent the reduction of pulmonary surfactant (PS). Conclusion: Acute mercury poisoning not only damages the kidneys, but also affects the lungs. The decrease of PS may be related to the increase of MDA. Compound salvia miltiorrhiza injection can inhibit this process, and then reduce the toxicity of mercury