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目的分析多囊卵巢综合征(PCOS)患者的胰岛素抵抗情况,为临床PCOS的诊治提供依据。方法选择在浙江省中医院内分泌科就诊的45例PCOS患者作为PCOS组,PCOS组合并有胰岛素抵抗者23例,无胰岛素抵抗者22例,选择同期进行健康体检的健康女性45例作为对照组,对照组有胰岛素抵抗者6例,无胰岛素抵抗者39例。对PCOS组和对照组进行糖耐量实验和胰岛素释放实验,比较两组患者的血糖水平和血清胰岛素水平。结果 PCOS组的年龄、腹围和BMI稍高于对照组,但差异无显著性(P>0.05)。PCOS组的空腹、30 min、60 min、120 min和180 min血糖均高于对照组(P<0.05)。PCOS组的空腹、30 min、60 min、120 min和180 min胰岛素均高于对照组(P<0.05)。PCOS和胰岛素抵抗之间显著相关性(P<0.05)。结论胰岛素抵抗是PCOS发生发展的主要相关因素,对于PCOS患者应重视胰岛素抵抗的发生。
Objective To analyze the status of insulin resistance in patients with polycystic ovary syndrome (PCOS) and provide evidence for clinical diagnosis and treatment of PCOS. Methods Forty-five patients with PCOS who were treated in endocrinology department of Zhejiang Provincial Hospital of Chinese Medicine were selected as PCOS group, 23 patients with PCOS combined with insulin resistance and 22 patients without insulin resistance. 45 healthy women were selected as control group during the same period, Control group had insulin resistance in 6 cases, 39 cases without insulin resistance. The rats in PCOS group and control group were given glucose tolerance test and insulin release test. The blood glucose level and serum insulin level were compared between the two groups. Results The age, abdominal circumference and BMI in PCOS group were slightly higher than those in control group, but the difference was not significant (P> 0.05). The fasting, 30 min, 60 min, 120 min and 180 min blood glucose in PCOS group were higher than those in control group (P <0.05). Fasting fasting, 30 min, 60 min, 120 min and 180 min insulin in PCOS group were higher than those in control group (P <0.05). There was a significant correlation between PCOS and insulin resistance (P <0.05). Conclusion Insulin resistance is the main factor related to the development of PCOS. The incidence of insulin resistance should be emphasized in patients with PCOS.