目的　探讨男性系统性红斑狼疮 (SLE)的临床特点。方法　对 79例男性和 6 12例女性SLE患者进行对比研究。结果　男性患者面部红斑、光敏发生率低 ,胸膜炎和心包炎多于女性。肾脏损害、尿蛋白定量、Ⅳ、Ⅴ型狼疮性肾炎比率、抗Sm阳性、病死率明显高于女性。好转率低于女性。结论　男性SLE临床表现不典型 ,肾脏损害较重 ,预后较差。 Objective To investigate the clinical features of male systemic lupus erythematosus (SLE). Methods A total of 79 male and 612 female SLE patients were compared. Results Male patients with facial erythema, the incidence of photosensitivity is low, pleurisy and pericarditis than women. Renal damage, urinary protein, Ⅳ, Ⅴ type lupus nephritis rate, anti-Sm-positive, mortality was significantly higher than women. Improvement rate lower than women. Conclusion The clinical manifestations of male SLE are not typical, with severe renal damage and poor prognosis.