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目的:观察注射用黄芪多糖联合吉西他滨加顺铂方案治疗晚期非小细胞肺癌的疗效和毒副反应。方法:治疗组GP方案即吉西他滨(择菲)1000mg.m-2第1、8天,顺铂25mg.m-2第1～3天+注射用黄芪多糖250mg静滴,每天1次,连用6周,对照组单用GP方案。结果:两组疗效差异无显著性(P>0.05);治疗组血液毒性和消化道反应发生率明显低于对照组,差异有显著性(P<0.05);生活质量评分治疗组高于对照组,两组间差异有显著性(P<0.05)。结论:注射用黄芪多糖联合GP方案治疗晚期非小细胞肺癌可降低化疗对患者的毒副反应,改善患者的生活质量。
OBJECTIVE: To observe the curative effect and toxicity of astragalus polysaccharide injection combined with gemcitabine and cisplatin in the treatment of advanced non-small cell lung cancer. Methods: The GP regimen of the treatment group was Gemcitabine (choose phenanthrene) 1000mg.m-2 on the 1st and the 8th day, cisplatin 25mg.m-2 on the 1st to 3rd days + Astragalus polysaccharide for injection 250mg intravenously once a day, Week, control group alone GP program. Results: There was no significant difference between the two groups (P> 0.05). The incidence of hematotoxicity and gastrointestinal reaction in the treatment group was significantly lower than that in the control group (P <0.05), and the quality of life score was higher in the treatment group than in the control group , There was significant difference between the two groups (P <0.05). Conclusion: Astragalus polysaccharide injection combined with GP regimen in the treatment of advanced non-small cell lung cancer can reduce the toxic side effects of chemotherapy and improve the quality of life of patients.