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目的：观察低剂量5-氟脲嘧啶（5—FU）持续输注联合低剂量顺铂（PDD）方案治疗晚期消化道恶性肿瘤的疗效。方法：5－FU250mg．m－2．d－1，持续深静脉输注3～4周。PDD6mg．m-2．d-1，静脉输注1小时，每周用5天，连用3～4周。以上方案连用二周期为一疗程，化疗后休息1个月评定疗效。结果：全组24例，总有效率为54．17％，其中PR13例。胃癌、食管癌、结肠癌的有效率分别为：64.29％、50．00％、33．33％；肝转移灶的有效率较高为75．00％。中位缓解期4．5个月（2～8个月）。没有Ⅲ°～Ⅳ°毒副反应发生。结论：认为低剂量5－FU持续输注联合低剂量PDD方案治疗晚期消化道恶肿瘤是一个有效低毒的化疗方案。
Objective: To observe the efficacy of low-dose 5-fluorouracil (5-FU) continuous infusion combined with low-dose cisplatin (PDD) regimen in the treatment of advanced gastrointestinal cancer. Method: 5-FU 250mg. M-2. D-1, continuous deep vein infusion for 3 to 4 weeks. PDD6mg. M-2. D-1, intravenous infusion for 1 hour, 5 days per week for 3 to 4 weeks. The above protocol was used in conjunction with two cycles as a course of treatment, and the efficacy was evaluated after one month of rest after chemotherapy. Results: In the whole group of 24 cases, the total effective rate was 54.17%, including 13 cases of PR. The effective rates of gastric cancer, esophageal cancer, colon cancer were: 64.29%, 50.00%, 33.33%; the effective rate of liver metastases was 75.00%. The median remission period is 4.5 months (2 to 8 months). No toxicities of III° to IV° occurred. Conclusion: It is considered that low-dose 5-FU continuous infusion combined with low-dose PDD regimen is an effective and low-toxic chemotherapy for the treatment of advanced digestive tract malignant tumors.