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目的:了解急性心肌梗死(AMI)的季节性和日内时间性发病规律,探讨其与循环树突状细胞功能的关系。方法:收集272例AMI住院病例,对不同季节(分1~3月,4~6月,7~9月和10~12月4季)和日内时间段(分0∶01~6∶00,6∶01~12∶00,12∶01~18∶00、18∶01~24∶004个时段)的发病率进行比较和统计;检测血循环树突状细胞的功能。结果:AMI患者1~3月和10~12月发病率明显高于4~6月和7~9月,P<0.01)。日内发病率以6∶01~12∶00明显高于其他时间段(P<0.01)。患者和正常对照组循环树突状细胞的功能亦呈明显的季节和日内时间规律。AMI的季节和日内发病比例变化与树突状细胞的功能变化高度相关。结论:AMI的发病率有冬春季明显高于夏秋季、日内以6∶01~12∶00明显高于其他时间段的规律特征,树突状细胞介导的免疫炎症反应可能是这一规律的机制之一。
Objective: To investigate the seasonal and intra-temporal patterns of acute myocardial infarction (AMI) and its relationship with the function of dendritic cells. Methods: A total of 272 AMI inpatients were enrolled in this study. The clinical data of 272 patients with acute myocardial infarction (AMI) were collected and analyzed in different seasons (from January to March, from April to June, from July to September and from October to December) and intraday (0:01 to 6:00, 6:01 ~ 12:00, 12:01 ~ 18:00, 18:01 ~ 24:00 4 time periods) were compared and statistically analyzed; the function of circulating dendritic cells was detected. Results: The incidence of AMI in patients from January to March and from October to December was significantly higher than that in April to June and from July to September (P <0.01). The intraday incidence rate was significantly higher than other time periods from 6:01 to 12:00 (P <0.01). The function of circulating dendritic cells in patients and normal control group showed obvious seasonal and intra-day time regularity. The seasonal and intraday rates of AMI are highly correlated with functional changes of dendritic cells. Conclusion: The incidence of AMI in winter and spring was significantly higher than that in summer and autumn, and the intra-day 6:01 ~ 12:00 was significantly higher than the regular patterns of other time periods. The dendritic cell-mediated immune inflammatory reaction may be the rule One of the mechanisms.