目的初步评估龙舌兰酒中甲醇的急性和慢性暴露健康风险。方法通过毒性资料检索与分析,确定甲醇的人体经口暴露急性和慢性限量值,参照我国居民酒精类饮料的消费模式,以我国饮酒者的白酒高端消费量代替龙舌兰酒高端消费量,基于专家咨询结果,选择龙舌兰酒中甲醇限量值3.0 g/L为龙舌兰酒中甲醇含量最大值(以100%酒精计),计算我国成人饮酒者经龙舌兰酒一次摄入甲醇的量;以我国饮酒者的白酒平均消费量代替龙舌兰酒平均消费量,结合已发表文献的龙舌兰酒中甲醇含量的平均值1.8 g/L(以100%酒精计),计算我国成人饮酒者经龙舌兰酒慢性摄入甲醇的量。结果我国居民通过饮用龙舌兰酒一次性摄入的甲醇为11.25 mg/kg BW,低于一次经口暴露限量(20 mg/kg BW);慢性摄入的甲醇为1.69 mg/kg BW,低于推荐的甲醇每日参考剂量(2.0 mg/kg BW)。结论我国成人饮酒者通过龙舌兰酒摄入甲醇的急性暴露和慢性暴露的健康风险较低。 Objective To assess the health risks of acute and chronic exposure to methanol in tequila. Methods Through the retrieval and analysis of toxicity data, the limits of acute and chronic oral exposure of methanol to human beings were determined. According to the consumption patterns of alcohol consumption in China, the high-end consumption of liquor in China was used to replace the high-end consumption of tequila. Expert consultation results, the choice of methanol in the tequila limited value of 3.0 g / L of the maximum methanol content of tequila (100% alcohol), calculate the consumption of alcohol in China once through the tequila alcohol Based on the average consumption of liquor in China instead of the average consumption of tequila and the average methanol content of tequila in published literature of 1.8 g / L (calculated as 100% ethanol) The amount of alcohol consumed by drinkers through tequila chronically. Results The residents of our country consumed 11.25 mg / kg BW of methanol, which was lower than the limit of oral exposure (20 mg / kg BW) once consuming tequila. The chronic methanol intake was 1.69 mg / kg BW, The recommended daily reference dose of methanol (2.0 mg / kg BW). Conclusion Our country adult drinkers have a lower health risk of acute exposure and chronic exposure to methanol through tequila.