www.colorcon.com.cn1简介兰索拉唑是一种质子泵抑制剂(PPI),常用于治疗胃和十二指肠溃疡。兰索拉唑胶囊由TAP制药产品公司推向市场,商品名Prevacid、Inhibitol和Zoton,规格为15和30 mg,可每1 d给药1次或多次。虽然兰索拉唑可溶于甲醇,但几乎不溶于水。其在水溶液中的稳定性具有pH依赖性,降解速率随pH值降低而增加。胃内的酸性环境可引起兰索拉唑显著降解,从而导致其本身的生物利用度和临床疗效降低。 www.colorcon.com.cn1 Introduction Lansoprazole is a proton pump inhibitor (PPI), commonly used in the treatment of gastric and duodenal ulcers. Lansoprazole capsules are marketed by TAP Pharmaceuticals, Inc. under the trade names Prevacid, Inhibitol and Zoton at 15 and 30 mg and may be given 1 or more times every 1 d. Although lansoprazole is soluble in methanol, it is almost insoluble in water. Its stability in aqueous solution is pH-dependent, and its degradation rate increases with decreasing pH value. The acidic environment in the stomach can cause significant degradation of lansoprazole, leading to its own bioavailability and clinical efficacy decreased.