研究表明,80%的肝细胞癌(hepatocellular carcinoma,HCC)是由于肝纤维化和炎症引起的~([1])。肝星状细胞可被肝损伤等激活为肌成纤维细胞样表型,活化的肝星状细胞可参与肿瘤微环境的形成~([2]);肿瘤血管生成与肿瘤微环境的形成 Research shows that 80% of hepatocellular carcinoma (HCC) is due to liver fibrosis and inflammation ~ ([1]). Hepatic stellate cells can be activated into myofibroblast-like phenotype by liver injury, activated hepatic stellate cells can participate in the formation of tumor microenvironment ~ ([2]); tumor angiogenesis and tumor microenvironment formation