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目的:考察艾片的体外黏膜渗透性及影响因素。方法:选择离体牛蛙腹皮为渗透模型,采用改良的Franz扩散池进行体外黏膜实验;GC测定艾片中龙脑的含量,研究接收液的不同pH值、温度、搅拌速度及药物浓度对艾片体外黏膜渗透的影响。结果:搅拌速度对艾片的渗透有一定的影响;而接收液的pH值、温度及药物浓度对艾片的渗透无影响。艾片黏膜渗透性良好,累积渗透率与时间符合一级吸收过程。结论:离体牛蛙腹皮可作为艾片的体外黏膜渗透性研究的实验模型。
Objective: To investigate the in vitro mucosal permeability and its influencing factors of Ai tablets. Methods: The in vitro model of bullfrog abdomen skin was selected, and the modified Franz diffusion cell was used for mucosal in vitro. GC was used to determine the content of borneol in the tablet. The effects of different pH, temperature, stirring speed and drug concentration Effect of in vitro mucosal infiltration. Results: The stirring speed had some influence on the penetration of the tablets. However, the pH value, the temperature and the drug concentration did not affect the penetration of the tablets. Alzheimer’s mucosal permeability is good, the cumulative permeability and time consistent with an absorption process. Conclusion: In vitro bullfrog belly skin can be used as an experimental model for the in vitro mucosal permeability test of Alzheimer’s disease.