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食品安全问题受到世界各国的关注,随着新食物产品的不断开发研究,关于是否会增加人体致敏风险等问题成为众专家学者竞相争论的焦点,啮齿类动物模型以其特有的优势在食物致敏性评价中占有重要位置,本文例举了BN大鼠、Balb/c小鼠、C3H/HeJ小鼠此三类最具代表性的啮齿类动物模型,并对致敏过程中常见致敏原及其影响因素、致敏途径和体内检测指标作一综述,为食品致敏性评价提供参考。
With the continuous development of new food products, the issue of food safety has become the focus of debate among experts and scholars on whether it will increase the risk of human sensitization. Rodent models, with their unique advantages in food-induced Sensitivity evaluation occupies an important position, this article exemplified BN rats, Balb / c mice, C3H / HeJ mice the most representative of the three types of rodent models, and sensitization process common allergens And its influencing factors, sensitization pathways and in vivo detection indicators for review, provide a reference for the evaluation of food allergenicity.