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以往的研究证明HBeAg阳性与肝炎的活动性及高度传染性有关,抗-HBe阳性时肝功能也随之恢复正常,提示慢乙肝中抗-HBe的出现有临床意义.在免疫抑制的抗-HBe阳性携带者,可以发生HBV再活动.晚近研究表明,慢乙肝患者在近期内转化为抗-HBe阳性后也可自然发生再度活动,且常伴发肝炎的严重恶化.因此,作者在一大系列连续的肝炎患者中观察在血清转为抗-HBe阳性后慢性HBV感染的转归HBV再活动的发生率及其对肝病的影响.方法:作者从1972～1984年意大利Padova内科医院连续223例有临床和生化特征的慢性肝炎住院患者中选出70例.HBsAg及HBeAg阳性,并符合以下标准:1.血清转氨酶持续高于正常2倍12个月以上;2.开始随访时肝活检符合慢性肝炎;3.首次活检后连续随访至少12个月;4.排除酒精性和其他可能造成慢性肝炎
Previous studies have shown that HBeAg-positive hepatitis activity and highly contagious, anti-HBe positive liver function also returned to normal, suggesting that the emergence of anti-HBe in chronic hepatitis B has clinical significance.In immunosuppressive anti-HBe Positive carriers can occur HBV reactivation.Recent studies have shown that patients with chronic hepatitis B in the near future into anti-HBe positive after the re-activity can occur naturally, and often accompanied by severe deterioration of hepatitis.Therefore, the author in a large series To investigate the incidence of HBV reactivation and its impact on liver disease in patients with chronic hepatitis B after serum switch to anti-HBe positive.Methods: From 1972 to 1984, a total of 223 consecutive patients Clinical and biochemical characteristics of patients with chronic hepatitis selected 70 cases.HBsAg and HBeAg positive and meet the following criteria: 1. Serum aminotransferase continued to be higher than normal 2 times more than 12 months; 2 start follow-up liver biopsy consistent with chronic hepatitis ; 3. Follow-up after the first biopsy for at least 12 months; 4. Exclusion of alcoholism and other possible causes of chronic hepatitis