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目的··:研究酒精对伏核神经元的影响 ,初步探讨酒精依赖的生物学机制。方法 :·· 以两倍阈强度电刺激大鼠脑片嗅结节区 ,记录伏核神经元的传入电活动 ,观察3种浓度的酒精对该传入电位的影响 ,并分析了44mmol·L-1 的酒精对此传入电位的时间 -强度变化曲线。结果··:(1)酒精能降低伏核神经元传入电位的幅值 ;(2)44mmol·L -1酒精对伏核神经元传入电位的抑制作用最强 ;(3)44mmol·L-1 的酒精在作用9 -17min时发挥了最大抑制作用。结论·· :酒精能抑制伏核神经元的传入电活动 ,且此作用可能与酒精依赖的形成有关
Objective · ·: To study the alcohol on the nucleus accumbens neurons, preliminary study of the biological mechanism of alcohol dependence. Methods: · Electrical stimulation of olfactory nodules in rat brain slices was induced by twice the threshold intensity. The afferent activities of nucleus accumbens were recorded. The effects of three concentrations of ethanol on the afferent potential were observed. L-1 alcohol on the incoming potential of the time - intensity curve. Results: (1) Alcohol decreased the amplitude of afferent potential of nucleus accumbens. (2) 44 mmol·L -1 alcohol had the strongest inhibitory effect on afferent potential of nucleus accumbens. (3) -1 alcohol in the role of 9 -17min exerted the maximum inhibitory effect. Conclusion ·· Alcohol can inhibit the afferent electrical activity of nucleus accumbens and this effect may be related to the formation of alcohol dependence