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目的探讨脑梗死伴发脑白质疏松症(LA)与血清尿酸的相关性。方法 150例脑梗死患者,对其行头颅CT检查及血清尿酸测定。且按照L.O.Wahlund CT脑白质疏松评分分为两组,0分为不伴脑白质疏松症组(NLA组,53例),其余为伴发脑白质疏松症组(LA组,97例)。观察两组血清尿酸水平。结果 LA组高尿酸血症患者29例(29.90%),明显多于NLA组的8例(15.09%)(P<0.05)。LA组患者平均年龄(70.25±4.88)岁,大于NLA组的(63.72±6.13)岁,血清尿酸水平(452.67±57.98)μmol/L高于NLA组的(360.28±63.71)μmol/L,差异均具有统计学意义(P<0.01)。血清尿酸与脑白质评分呈正相关(r=0.634,P=0.002<0.01)。结论血清尿酸与脑梗死伴发LA有关,血清尿酸水平越高,脑白质疏松程度越高。
Objective To investigate the correlation between cerebral infarction and leukoaraiosis (LA) and serum uric acid. Methods 150 patients with cerebral infarction, their head CT examination and serum uric acid determination. According to L.O.Wahlund CT leukoaraiosis score, the patients were divided into two groups. 0 was divided into group without leukoencephalopathy (NLA group, n = 53) and the rest with leukoaraiosis group (group LA, 97 cases). Serum uric acid levels were observed in both groups. Results In the LA group, 29 cases (29.90%) had hyperuricemia, which was significantly more than that in the NLA group (15.09%) (P <0.05). The mean age of patients in LA group was (70.25 ± 4.88) years, significantly higher than that in NLA group (63.72 ± 6.13), and serum uric acid level (452.67 ± 57.98) μmol / L was higher than that in NLA group (360.28 ± 63.71 μmol / L) With statistical significance (P <0.01). Serum uric acid and white matter score was positively correlated (r = 0.634, P = 0.002 <0.01). Conclusions Serum uric acid is associated with cerebral infarction associated with LA. The higher the level of serum uric acid, the higher the degree of leukoaraiosis.