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全身照射治疗(TBI)已应用于同化疗联合杀灭肿痛细胞和骨髓移植前用于杀灭骨髓干细胞和有免疫原性的细胞。对异体或自体骨髓移植所用的全身照射技术和剂量是相同。TBI主要适应证包括某些高危的急性白血病,某些慢性白血病(如慢性髓细胞性白血症)和某些实体肿瘤(如淋巴瘤、神经母细胞瘤)。从二十年代起人们就已开始应用TBI技术,最初使用的参考剂量为10Gy,低剂量率,在数小时内给予。事实上,在这种剂量水平照射下,不治疗的话,在数周内仅由于造血系统损害而导致患者死亡,骨髓移植可拮抗TBI对血液系统的毒性作用。TBI和骨髓移植后,主要并发症的危险器官是肺,即发生间质性肺炎。低剂量率照射10Gy的效力,在生物学上,估计可杀灭约10~4骨髓干细胞
Whole Body Radiation Therapy (TBI) has been applied to kill tumor cells and kill bone marrow stem cells and immunogenic cells before combined with chemotherapy. The total body irradiation technique and dose used for allogeneic or autologous bone marrow transplantation are the same. The main indications for TBI include certain high-risk acute leukemias, certain chronic leukemias (such as chronic myelogenous leukemia), and certain solid tumors (such as lymphoma, neuroblastoma). Since the 1920s, people have begun to apply TBI technology, the initial reference dose of 10Gy, low dose rate, given within a few hours. In fact, at this dose level, without treatment, the patient died only a few weeks after hematopoietic system damage. Bone marrow transplantation can antagonize the toxic effects of TBI on the blood system. After TBI and bone marrow transplantation, the major organ of the major risk of complications is the lung, ie interstitial pneumonia. The efficacy of low dose rate irradiation of 10 Gy is biologically estimated to kill approximately 10 to 4 bone marrow stem cells.