食管癌在我国的发病率很高,河北省太行山区磁县的年死亡率为131。3/10万,有些公社高达240/10万以上,故有必要对食管癌的病因和癌变过程继续进行深入观察和研究。文献报导昆明种小白鼠对甲基苄基亚硝胺有较高的敏感性。本研究使用荧光、组化和电镜等方法重点对该种亚硝胺所诱发的小鼠食管和前胃粘胶上皮增生、癌变的形态学特征作综合观察和分析,并就所观察到的主要变化进行讨论。 The incidence of esophageal cancer is high in China. The annual mortality rate in Cixian, Taihang Mountain, Hebei Province is 131. 3 per 100,000, and some communes are as high as 240 per 100 000. Therefore, it is necessary to continue the etiology and carcinogenesis of esophageal cancer. In-depth observation and study. The literature reports that Kunming mice have high sensitivity to methylbenzylnitrosamines. In this study, fluorescence, histochemistry, and electron microscopy were used to focus on the morphological characteristics of the oesophageal and epigastric hyperplasia and carcinogenesis induced by nitrosamines in mice, and the main observations were made. Change to discuss.