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目的探讨大剂量丙种球蛋白联合纳洛酮治疗重度病毒性脑炎的临床效果。方法选取2011年8月—2015年9月瑞昌市人民医院收治的重度病毒性脑炎患者31例,根据治疗方法不同分为对照组15例与研究组16例。对照组患者给予常规综合治疗,研究组患者在对照组基础上给予大剂量丙种球蛋白联合纳洛酮治疗。观察治疗后两组患者退热、住院天数、惊厥控制、头痛呕吐消失、意识转清时间及临床疗效,比较两组患者不良反应发生情况。结果研究组患者退热、住院天数、惊厥控制、头痛呕吐消失、意识转清时间均短于对照组,总有效率高于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论大剂量丙种球蛋白联合纳洛酮治疗重度病毒性脑炎的临床效果显著,可提高治疗效果,改善患者免疫功能,且不良反应少。
Objective To investigate the clinical effect of high-dose gamma globulin combined with naloxone on severe viral encephalitis. Methods Totally 31 patients with severe viral encephalitis admitted to Ruchang People’s Hospital from August 2011 to September 2015 were divided into control group (n = 15) and study group (n = 16) according to different treatment methods. Patients in the control group were given conventional comprehensive treatment. Patients in the study group were given high-dose gamma globulin combined with naloxone on the basis of the control group. Two groups of patients were observed after treatment fever, hospital days, convulsions control, vomiting disappeared headache, consciousness to clear the time and clinical efficacy, the incidence of adverse reactions in both groups were compared. Results The study group patients with fever, hospital days, convulsions control, headache vomiting disappear, consciousness to clear time shorter than the control group, the total effective rate was higher than the control group, the difference was statistically significant (P <0.05); two groups of patients with poor There was no significant difference in response rate (P> 0.05). Conclusion The clinical effect of high-dose gamma globulin combined with naloxone in the treatment of severe viral encephalitis is significant, which can improve the therapeutic effect and improve the immune function of patients with less adverse reactions.