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胰岛素抵抗普遍存在于2型糖尿病患者中,主要表现为在肌肉、肝脏和脂肪细胞胰岛素抵抗。在2型糖尿病发病过程中,胰岛素抵抗与胰岛素分泌程度间呈相互依赖的双曲线关系,即组织胰岛素抵抗可通过胰岛素分泌代偿性性增加来维持血糖水平稳定。其中骨骼肌在餐后胰岛素介导的葡萄糖摄取中占主要地位。本文就骨骼肌胰岛素抵抗的发病机制和临床处理进行综述。1骨骼肌和葡萄糖稳态正常情况下,摄食或糖负荷后刺激胰岛素分泌,胰岛素与骨骼肌细胞膜上胰岛素受体结合,引起受体自身磷酸化及酪氨酸蛋白激酶活化,从而使胰岛
Insulin resistance is prevalent in patients with type 2 diabetes, mainly manifested as insulin resistance in muscle, liver and adipocytes. In the pathogenesis of type 2 diabetes, there is an interdependent hyperbolic relationship between insulin resistance and insulin secretion, that is, tissue insulin resistance can maintain stable blood glucose level through the compensatory increase of insulin secretion. Skeletal muscle predominates in postprandial insulin-mediated glucose uptake. This article reviews the pathogenesis and clinical management of skeletal insulin resistance. 1 skeletal muscle and glucose homeostasis under normal circumstances, feeding or sugar load stimulates insulin secretion, insulin and skeletal muscle cell membrane insulin receptor binding, causing the receptor autophosphorylation and tyrosine kinase activation, so that islet