FⅧ抑制物是一种可以抑制或中和F血凝血活性的同种抗体或自身免疫抗体[1]。同种抗体见于部分先天性血友病甲患者；自身免疫抗体见于非血友病患者，由此引起的疾病亦称之为获得性血友病。FⅧ抑制物一旦形成，常规治疗方法时常不能有效地控制出血，成为临床棘手的问题。1FⅧ抑制 FⅧ inhibitor is an alloantibody or autoimmune antibody that inhibits or neutralizes F blood clotting activity [1]. Alloantibodies found in some patients with congenital hemophilia A; autoimmune antibodies found in non-hemophiliacs, the resulting disease is also known as acquired hemophilia. Once the formation of FⅧ inhibitors, conventional treatment methods often can not effectively control bleeding, become a clinical problem. 1F Ⅷ inhibition