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目的 探讨镁在脑梗死发病机制中的作用。方法 对 30例急性期脑梗死患者和 2 5例正常对照采用火焰原子吸收法测定了血清镁、红细胞镁、血小板镁水平。结果 急性期脑梗死患者血清镁、红细胞镁、血小板镁水平均低于对照组 (P<0 .0 1)。相关分析发现血清镁与红细胞镁、血小板镁水平呈直线正相关 (r=0 .75 2和 r=0 .6 0 4,P<0 .0 1)。结论 急性脑梗死患者处于低镁状态 ,血小板镁降低可能是血小板功能异常、活化性增强的原因之一 ,提示急性脑梗死补镁治疗有重要意义
Objective To explore the role of magnesium in the pathogenesis of cerebral infarction. Methods Serum levels of magnesium, erythrocyte magnesium and platelet magnesium in 30 patients with acute cerebral infarction and 25 normal controls were measured by flame atomic absorption spectrometry. Results The levels of serum magnesium, erythrocyte magnesium and platelet magnesium in patients with acute cerebral infarction were lower than those in the control group (P <0.01). Correlation analysis showed that there was a linear positive correlation between serum magnesium and magnesium in erythrocytes and magnesium in platelets (r = 0.75 2 and r = 0.604, P <0.01). Conclusions Patients with acute cerebral infarction are in a state of low magnesium, and the decreased platelet magnesium may be one of the causes of abnormal platelet function and activation, suggesting that magnesium supplementation in acute cerebral infarction is of great significance