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由于~(237)Np的物理半衰期很长(2140000年),且它的生理和环境的可利用性,近来又重新引起人们的关注。为了预测镎对人群可能造成的危害以及饮食因素对它吸收的影响,作者选择了灵长类的狒狒作为实验对象,进行了实验。(年龄3～7岁,体重3.5～13公斤)。为了避免粪便污染,动物于实验前两周经外科手术切除尾巴,并于灌胃前剃去面部毛发。用~(237)Np和~(239)Np两种同位素按不同剂量(0.00128、0.0014、0.00424、0.00427、431和769μg/kg体重,体积为1mL)插管灌胃。然后置代谢笼内,每日收集大小便。其中选用5只狒狒给予不同剂量的~(+3)Fe(20、65和100mg/kg),观察它们对~(239)Np在胃肠道吸收的影响;设对照组(4只):饲正常饮食;实验组又分
Due to the long physical half-life of ~ (237) Np (2140000 years) and its physiological and environmental availability, it has recently gained renewed attention. In order to predict the possible harm to humans and the effects of dietary factors on their absorption, the authors selected primate baboons as experimental subjects. (Age 3 to 7 years old, weighing 3.5 to 13 kg). To avoid faecal contamination, animals undergo surgical removal of the tail two weeks prior to the experiment and shave the facial hair before gavage. The two kinds of isotopes of ~ (237) Np and ~ (239) Np were intragastrically administered at different doses (0.00128, 0.0014, 0.00424, 0.00427, 431 and 769 μg / kg body weight, volume of 1 mL) Then set the metabolism cage, daily urine collection. Among them, 5 baboons were given different doses of ~ (+3) Fe (20, 65 and 100 mg / kg) to observe their effect on gastrointestinal uptake of 239 Np. The control group (4) Normal diet; experimental group is divided